“Designing 4D printed drug delivery systems based on smart polymers and hydrogels: principles, strategies, and future perspectives”

Authors & Investigators

Turdimuhammad Abdullah★Ayimgül UzunyolSuleyman HekimCemil DizmanGamze AydinOguz OkayAdnan Memic

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Official Venue

Progress in Biomedical Engineering

Publisher: IOP Publishing

Abstract & Research Summary

The development of advanced drug delivery systems (DDS) has revolutionized pharmaceutical applications by enabling precise, controlled, and targeted drug release.Polymer-based biodegradable systems have garnered notable attention within the field due to their inherent biocompatibility and the capacity to facilitate localized and sustained drug administration. Nonetheless, their widespread clinical adoption is hindered by challenges such as uncontrolled drug release kinetics, limited patient-specific customization, and scalability constraints. 3D printing overcomes these limitations by offering unparalleled design flexibility and customization, while 4D printing further addresses dynamic control challenges by enabling stimuli-responsive drug carriers for precise and targeted release. This review offers a comprehensive overview of 4D printing technologies for drug delivery applications, with a particular focus on a …

Cite This Publication

@article{abdullah2026designin,
  title = {Designing 4D printed drug delivery systems based on smart polymers and hydrogels: principles, strategies, and future perspectives},
  author = {Turdimuhammad Abdullah, Ayimgül Uzunyol, Suleyman Hekim, Cemil Dizman, Gamze Aydin, Oguz Okay, Adnan Memic},
  journal = {Progress in Biomedical Engineering},
  year = {2026},
  publisher = {IOP Publishing},
  doi = {10.1088/2516-1091/aea7ea},
  url = {https://doi.org/10.1088/2516-1091/aea7ea},
}